- "You`re a crook, Meningitis."
"I am not a crook. Besides, I`m Emperor. If I do it, It`s not illegal"
- ―Crypto and Meningitis[src]
Emperor Meningitis was mentioned several times in the series but was known solely as "The Emperor" and did not appear for some quite time. In Destroy All Humans!, Meningitis sent Orthopox and Crypto 137 to Earth in order to collect pure Furon DNA from Human Brain Stems.
In Destroy All Humans! 2, Crypto 138 and Pox continued their mission further, but little mention was made of Meningitis. It was revealed, however, that Meningitis had cut the Furon Empire’s budget for defense and weaponry after the Martian War.
Years later, a renegade Furon known as The Master hatched a plan upon finally encountering Crypto 139 via mental messages. The Master influenced Crypto into siding with him, implying that Meningitis himself was behind the recent attacks of the Nexosporidium Warriors and that he had been in possession of “Synthetic Furon DNA,” which meant that Crypto and Pox had wasted over 20 years trying to acquire DNA that was no longer needed.
Eager for revenge, Crypto and Pox arrived at the Fourth Ring of Furon, home to Meningitis' Summer Palace. After Crypto and Pox caused havoc around the area, they finally broke through the palace's defenses and confronted the Emperor.
Meningitis questioned why Crypto and Pox were there and the reason that Crypto (whose name was believed by the forgetful Meningitis to be Klepto) repeatedly insulted him. When Crypto explained his thirst for revenge, Meningitis shrugged his words off by asserting the fact that he had no idea what they were talking about and said that since he was Emperor, if he did something, it wasn't illegal.
Crypto then prepared to shoot Meningitis, who then pressed a switch on his staff that activated a giant, mechanical bust of himself that protruded from the ceiling, which he began piloting. Crypto, after he used his new mental abilities, regained his weapons, bypassed the security system, destroyed the robotic head and grabbed Meningitis while he lay on the floor, defeated.
Crypto violently shook Meningitis and demanded to know how long he had Synthetic DNA. Meningitis urged Crypto to be careful, as he was 500 years old, before disintegrated into dust. Crypto then exclaimed angrily and was soon dumbstruck when the Master himself reappeared out of the green necklace that he wore: it was a one-off cloning device that the Master had imprinted himself on after he staged his death and won Crypto's favor, all of which was a part of his plan to become the new Emperor by using Crypto to get close to Meningitis and inside the palace.
Pox, in his new half-primate body, smashed the gloating Master against a wall, ending his traitorous scheme, and took up the throne of Emperor.
Upon learning that the Synthetic DNA caused Furons to become violently sick, Crypto set out on another ten year journey to collect more, non-synthetic DNA. Meanwhile, the citizens of Furon praised the death of Meningitis and happily rushed in to hail Emperor Orthopox, despite the fact that he now had the body of an ape.
Meningitis had the typical characteristics of a senile old man: forgetful and very cranky. He was quite tyrannical, above the law, and declared himself to be exempt from all Furon Laws.
While the details of his reign weren't clear, it's quite apparent that Meningitis must have been disliked enough for the populace to instantly praise a monkey-fied Orthopox.
- "Careful, I’m five hundred years old!"
- ―Meningitis moments before he crumbles to dust[src]
Meningitis had the same facial appearance as all Furons, with dark red eyes and an elongated cranium. Meningitis' face was quite wrinkled, which was an indicator of his age. He also appeared to have a few small, tube-like protrusions that stuck out of the back of his head.
Meningitis was quite fragile, since he appeared to spend his time doing nothing at the palace. He wore a dark red robe, which was covered by a red cape with pointed shoulders and golden edges and carried a brown scepter with a blue orb on its tip, that called upon his special bust, which was made in his image.
- Meningitis was voiced by Nolan North.