Orthopox was the Furon Fleet Commander whom Emperor Meningitis chose to lead the mission to collect pure Furon DNA from Earth. Cyclosporiasis, the admiral in charge of Pox's Fleet, monitored Pox's mission to Earth and kept in touch with him so that he could file reports from the Mothership.
Cyclosporiasis was not seen in the game, but was heard over a transmitter. While Pox and Crypto tried to get a Mothership to pick them up from Earth, Pox got into an annoying argument with a space traffic control attendant. After he hung up, the call was taken by Cyclosporiasis. Cyclosporiasis was thrilled that Pox and Crypto had collected their assigned mission of pure Furon DNA and told Pox that he would prepare a transport to pick them up. Pox regrettably stated that when the Mothership blew up, all of the DNA that he had collected was also destroyed. Cyclosporiasis became angered by that and told Pox that maybe he should get another fleet commander to acquire the DNA and not send assistance. Pox protested against Cyclosporiasis' consideration to leave him to rot on Earth. Cyclosporiasis told Pox to not try and influence his decision. At the end of the call, Cyclosporiasis mentioned that he would send a Mothership to retrieve Pox when he got the chance and then hung up. Pox failed to hear that and believed that he and Crypto were stranded.
- Destroy All Humans! 2 (Heard on transmitter)